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Chemical Biology of Cell Division
Author(s) -
Kapoor Tarun
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a34-b
Subject(s) - cell division , microtubule , tubulin , division (mathematics) , asymmetric cell division , cell , microbiology and biotechnology , biophysics , chromosome segregation , microtubule polymerization , biology , biological system , chemistry , genetics , chromosome , gene , arithmetic , mathematics
The stable propagation of our genomes requires accurate cell division, a very dynamic cellular process. We combine the use of cell‐permeable small molecules, which inhibit their target proteins on fast time‐scales, and high‐resolution multi‐mode live cell microscopy to examine the regulation and force‐generating mechanisms required for error‐free partitioning of DNA into two daughter cells. The cell division functions of Aurora and Polo‐like kinases, microtubule‐based motor proteins and tubulin polymerization dynamics are analyzed using approaches at the interface of chemistry and biology.