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Peptoid Microarrays as Tools for Monitoring and Manipulating Proteome.
Author(s) -
Kodadek Thomas
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a34
Subject(s) - proteome , peptoid , computational biology , protein microarray , nanotechnology , dna microarray , function (biology) , computer science , protein array analysis , chemistry , bioinformatics , biology , materials science , microbiology and biotechnology , biochemistry , gene expression , peptide , gene
This lecture will focus on the construction and utility of microarrays comprised of thousands of different peptoids (oligo‐N‐substuted glycines) linked covalently to chemically modified glass slides. We will discuss how these arrays can be employed to identify high affinity protein ligands of utility for manipulating the function of the target proteins. We also describe how these arrays can be employed as analytical devices to monitor the response of sub‐proteomes to various physiological stimuli. Possible applications of these arrays in medical diagnostics will be discussed.