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Effect of low carbohydrate concentration and beverage osmolality on gastric emptying in euhydrated humans
Author(s) -
Shi Xiaocai,
Osterberg Kris L.,
Juan Deborah RagasaSan,
Murray Robert
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a331
Subject(s) - gastric emptying , carbohydrate , medicine , gastroenterology , stomach
Carbohydrate (CHO) concentration and beverage osmolality affect gastric emptying (GE). However, the effect of low CHO concentrations and beverage osmolalities on GE is not fully studied. PURPOSE: To investigate the effect of low CHO concentrations and beverage osmolalities on GE in euhydrated subjects at rest. METHODS The GE of water placebo (W) and three CHO‐electrolyte (E) solutions (2, 4, and 6% glucose+sucrose; glucose:sucrose ratio = 1:2) with the osmolalities ranged from 58 to 275 mOsmo/kg were determined in eight healthy subjects using the modified George double‐sampling technique. Subjects quickly („T1.5 min) ingested a beverage (7 ml/kg Body Weight) containing 25‐ppm phenol red and subsequent gastric samples were collected every 10 minutes for 40 minutes. Linear regression and an ANOVA with repeated measures were used for statistical analysis. RESULTS The gastric secretion volume was not significantly different among beverages across time. Although gastric CHO concentrations and osmolalities were significantly different among all test beverages across time, gastric residual volume (GRV) did not differ among 2, 4, 6% CHO‐E beverages and water (p>0.05). Gastric osmolality did not significantly change over time. Mean gastric osmolality and mean gastric CHO concentration did not correlate to mean GRV. CONCLUSION The data show that beverage osmolality at or below isotonicity does not significantly affect GE. CHO‐E beverages containing 2–6% combination of glucose and sucrose are emptied as fast as water. It seems that a higher osmolality and/or glucose level is needed for initiating a significant feedback inhibition on GE.