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Blood pressure resetting with a chip system in hypertensive rats
Author(s) -
Gao XingYa,
Wang HanJun,
Zhu GuoQing,
Zhang Feng Zhang,
Huang XingLin,
Wang Wei
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a308
Subject(s) - blood pressure , stimulation , medicine , mean arterial pressure , stimulus (psychology) , anesthesia , heart rate , cardiology , psychology , psychotherapist
We previously reported that an implanted close‐loop chip system used to control blood pressure was designed and evaluated. The chip system successfully reset the blood pressure and kept the blood pressure in a lower constant level in normal rabbits and rats. In the present study, we further evaluated the efficiency of the chip system on controlling blood pressure in 7 spontaneously hypertensive rats (SHR) and 8 two‐kidney, one‐clip hypertensive rats (2K1C) in the acute experiment. The chip system regulated blood pressure by electrical stimulating the aortic depressor nerve lasting for 60 minutes, and the frequency of stimulation instantaneously varied according to the feedback of mean arterial pressure (MAP). When MAP was between 80 and 160 mmHg, the frequency of stimulus increased following the elevation of MAP. When MAP exceeded 160 mmHg, the frequency of stimulation reached its maximal value (100 Hz). When MAP was less than 80 mmHg, the stimulation stopped automatically. There were immediately decreases of MAP (131±6 to 97±6 mmHg in SHR, and 145±14 to 95±9 mmHg in 2K1C rats) and HR (377±25 vs.346±15 bmp in SHR, and 368±28 vs.330 ±38 bpm in 2K1C rats) with little fluctuation during regulation. Both MAP and HR returned to the baseline immediately without rebound after the resetting ceased. The results indicated that the chip system successfully reset blood pressure in the normal level without adaptation in SHR and 2K1C rats. Supported by National Natural Science Fund and Jiangsu Education Fund in China and NIH grants # PO‐1 HL62222