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Active and passive elastic components of the vessel wall in trout arteries
Author(s) -
Meiss Richard A.,
Olson Kenneth R.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a301-a
Subject(s) - isometric exercise , circumference , anatomy , stiffness , trout , context (archaeology) , preload , mechanics , materials science , biomedical engineering , chemistry , mathematics , physics , biology , geometry , cardiology , composite material , hemodynamics , medicine , engineering , fishery , paleontology , fish <actinopterygii>
Mechanical properties of large arteries are determined by active and passive tissue components. We examined the activation‐dependent properties of efferent branchial arteries from the steelhead trout ( Oncorhynchus mykiss ). Short vessel segments were mounted in an apparatus providing a continuous measure of length (circumference), force, and stiffness. After being stretched to a preload previously determined to allow maximal isometric force, the vessels were activated with 80 mM KCl. When full isometric force had developed, circumference was quickly reduced until force was zero. Vessels were then stretched, stepwise, until total force was 50 mN. When a steady state was reached, the tissue was shortened in a similar stepwise manner; after each step force fell quickly and recovered exponentially. Following KCl washout, this sequence was repeated. Data analysis emphasized the shortening phase of the protocol; overall stiffness was a linear function of force over this whole range. During the recovery from each step, stiffness was also proportional to force, but the slope of the relationship was steeper. The slope increase was even greater for a relaxed vessel; its recovery, while smaller, was slightly faster. This behavior was largely independent of the circumference length. These results are considered in the context of a model containing elastic and time‐dependent elements. Supported by NSF Grant IBN 023‐5223 to K.R.O.