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Forearm blood flow responses in carriers of genetic polymorphisms of the NO pathway
Author(s) -
Hesse Christiane,
Fricker Ruth,
Weiss Johanna,
Tayrouz Yorki,
Hoffmann Michael M,
Haefeli Walter E
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a289-d
Subject(s) - forearm , blood flow , biology , genetics , medicine , anatomy
Polymorphisms of the NOSIII and CYBA gene have been associated with a number of pathological conditions such as arterial hypertension or coronary artery disease. Because endothelium‐dependent vasodilation is impaired in these disorders, we hypothesized that polymorphisms of genes involved in NO metabolism [ NOSIII (T‐786C, G894T, (CA) n )] or degradation [ CYBA (C242T)] might modulate endothelial function of arterial vessels already before cardiovascular disease becomes overt. 66 healthy Caucasians were included into the study after careful exclusion of cardiovascular risk factors (hypertension, hyperlipidemia, diabetes, hyperhomocysteinemia, smoking). Using venous occlusion plethysmography forearm blood flow responses to intra‐arterial infusion of acetylcholine (endothelium‐dependent vasodilation; 6 increasing dose‐rates), sodium nitroprusside (endothelium‐independent vasodilation; 6 dose‐rates) and L‐NMMA (basal NO release; 3 dose‐rates) were assessed. In all studied polymorphisms no significant difference between the respective genotypes and the forearm blood flow responses to either acetylcholine, L‐NMMA or sodium nitroprusside was observed. The studied polymorphisms of NOSIII and CYBA do not significantly modulate arterial reactivity in individuals without vascular risk factors. Supported in part by a Hans‐Dengler‐Research‐Scholarship (to C.H).