Premium
Sex‐specific differences in the reactivity of spinotrapezius arterioles to norepinephrine, sodium nitroprusside and 21% superfusate O 2 in male (M) and female (F) Sprague‐Dawley (SD) rats fed a low (LS, 0.4% NaCl) or high salt diet (HS, 4.0% NaCl)
Author(s) -
Kunert Mary Pat A
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a268-c
Subject(s) - sodium nitroprusside , endocrinology , medicine , vasodilation , norepinephrine , chemistry , microcirculation , acetylcholine , reactivity (psychology) , skeletal muscle , biology , nitric oxide , alternative medicine , pathology , dopamine
Hartford Avenue (UWM) 8701 Watertown Plank Rd (MCW), Shorewood, Wisconsin, 53211 High salt intake independent of an increase in blood pressure has been implicated as a cause of endothelial dysfunction that is a hallmark of many cardiovascular diseases that are expressed in a sexually dimorphic manner. We investigated sex based differences in the reactivity of arterioles of salt insensitive SD rats (intact male and female) in an in situ preparation of the spinotrapezius muscle to norepinephrine (NE), acetylcholine (ACh), sodium nitroprusside (SNP) and 21% superfusate O 2 . Arterioles of the HS F were more sensitive to NE than those of the HS M but not of the LS F. The % change in vessel diameter to increasing NE concentration was significantly greater in the arterioles of the LS F than in the LS M or the HS M. The arterioles of the F on a LS diet were more sensitive to SNP than those of the HS F and the LS M. The arterioles of the LS M were more sensitive to SNP than those of the HS M. The arterioles of the HS F constricted significantly more to elevated O 2 than those of either the LS F or the HS M. These studies demonstrate that there are sex‐based differences in skeletal muscle vascular reactivity and that those differences are influenced by the level of salt intake.