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The effects of the selective 5‐HT 1B receptor agonist, CP94253, on cocaine seeking and anxiety
Author(s) -
Acosta Jazmin I,
Gaudet Lyn,
Neisewander Janet L
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a236-b
Subject(s) - agonist , psychology , extinction (optical mineralogy) , elevated plus maze , craving , reinforcement , addiction , self administration , anxiety , pharmacology , stimulation , receptor , neuroscience , medicine , chemistry , psychiatry , social psychology , mineralogy
Exposure to cues associated with cocaine or cocaine itself can elicit incentive motivation that manifests as craving in humans and cocaine‐seeking behavior in animals. We have previously reported that a 5‐HT 1B/1A receptor agonist attenuates cocaine‐seeking behavior elicited by either cocaine cues or cocaine priming, and these effects are reversed by a 5‐HT 1B antagonist. However, we also casually observed that the nonselective agonist produced anxiety‐like behavior on the test day. Therefore, this study examined the effects of the selective 5‐HT 1B agonist, CP94253, on cue and cocaine‐primed reinstatement of extinguished cocaine‐seeking behavior, as well as anxiety‐like behavior using the elevated plus maze. Rats were trained to press a lever on a VR 5 schedule of cocaine (0.75 mg/kg, IV) reinforcement paired with light and tone cues. Rats then underwent extinction during which responses had no consequences and cocaine‐seeking behavior, defined as lever presses in the absence of cocaine reinforcement, declined across daily sessions. Rats were then tested for cue and cocaine‐primed (10 mg/kg, IP) reinstatement of cocaine‐seeking behavior and exploration of an elevated plus maze following pretreatment with an assigned dose of CP94253 (0.0–10.0 mg/kg, SC). CP94253 dose‐dependently attenuated cue and cocaine‐primed reinstatement of cocaine‐seeking behavior, as well as open arm entries on the elevated plus maze. These findings suggest that stimulation of 5‐HT 1B receptors may decrease motivation for cocaine, although it is not clear whether this effect is independent of, or secondary to, the drug’s anxiogenic effects. Supported by DA11064 and the Ford Foundation, MEG