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Multiplicity of benign breast lesions is a marker of risk for progression to breast cancer
Author(s) -
Worsham Maria J,
Lu Mei,
Raju Usha,
Kapke Alissa,
Wolman Sandra R
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a220
Subject(s) - breast cancer , medicine , oncology , pathology , cancer
A cohort of 4970 women, initially identified using surgical pathology reports with biopsy‐proven BBD, was studied for determination of subsequent development of breast cancer (BC). Subsequent to the index biopsy, 218 women were diagnosed with BC. Lesions classified as non‐proliferative (NP), proliferative (P), and as either ADH or ALH. The majority of BBD subjects (almost 70% in our cohort) have multiple lesions. Women with multiple NP and multiple P lesions (870 subjects) without atypia had 3‐fold risk of BC (RR=2.99, 95% CI 1.25, 7.17) and high significance (p=0.0142) as compared to the reference group (women with a single NP lesion {961 subjects}). Women with atypia as the sole lesion (17 subjects) did not show significant risk for BC progression (RR=2.86, 95% CI 0.10, 80.66). However, the risk for BC progression from BBD in women with AH in conjunction with multiple P lesions with or without NP was almost 7‐fold higher (RR=6.80, 95% CI 2.58, 17.90) and highly significant (p=0.0001). The significance and risks remained the same after adjusting for age in the analysis. In summary, multiplicity of BBD lesions may be considered a meaningful marker for risk of progression to BC.