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Relationship of Central Adiposity to Serum Ferritin and Antioxidant Enzymes in Postmenopausal Women
Author(s) -
Deardorff Betsy L,
Baig Asiya,
Ritland Laura,
Alekel D. Lee,
Reddy Manju B
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a191-b
Subject(s) - medicine , endocrinology , oxidative stress , glutathione peroxidase , waist , antioxidant , ferritin , superoxide dismutase , body mass index , chemistry , biochemistry
Oxidative stress is a major underlying cause of cardiovascular, cancer, and neurodegenerative diseases. Oxidative stress, iron stores, and body fat typically increase with age, especially after menopause. Excess iron stores and body fat may further induce oxidative stress by compromising antioxidant status. We determined the relationship between iron and antioxidant status and their associations with body composition. Antioxidant enzymes [erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX)], iron stores [serum ferritin (SF)], and body composition [BMI, waist circumference (WC), waist‐to‐hip ratio (WHR), sagittal diameter, and centrally deposited fat (via dual‐energy X‐ray absorptiometry)] were measured in healthy postmenopausal women (N=122). Spearman correlation analysis found significant positive correlations between SF and age (p=0.005), WC (p=0.01), WHR (p<0.0005), sagittal diameter (p<0.05), androidal fat (p<0.05), and andrioid‐to‐gynoidal fat ratio (p<0.005). However, no significant relationships were found between iron status and antioxidant enzymes. GPX was inversely associated with weight (p<0.01), BMI (p<0.05), sagittal diameter (p<0.0.05), and adroidal fat (p=0.05), but positively correlated (p<0.05) with CAT and SOD. Our results suggest that high iron stores do not compromise antioxidant status, whereas central adiposity appears to adversely affect antioxidant status. The direct association of SF to central adiposity (androidal fat) also warrants further investigation. Supported by American Heart Assoc & National Institute of Arthritis & Musculoskeletal and Skin Diseases/NIH