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Vitamins D Status in adolescents and young adults with HIV infection
Author(s) -
Stephensen Charles Bolt,
Marquis Grace S.,
Kruzich Laurie A.,
Douglas Steven D.,
Aldrovandi Grace M.,
Wilson Craig M.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a186-a
Subject(s) - medicine , vitamin d and neurology , body mass index , vitamin , vitamin d deficiency , physiology , cohort
Vitamin D status affects immune function and may thus affect the progression of HIV infection. Our goals were to assess vitamin D intake and status in subjects with HIV infection and in matched controls, and to determine if HIV infection was associated with vitamin D insufficiency. Plasma 25(OH) vitamin D and vitamin D intake were measured in a cross‐sectional study of members of the Reaching for Excellence in Adolescent Health (REACH) cohort. Subjects were 14 – 23 y of age, 74% were female and 72% were black. Mean vitamin D intake from food was 30% greater (p = 0.023) in HIV‐positive subjects (295 ± 18 IU/d, n = 237) than in HIV‐negative subjects (227 ± 26 IU/d, n = 121). The prevalence of vitamin D supplement use was 29% (104/358) and did not differ by HIV status (p = 0.87). Mean plasma 25(OH) vitamin D did not differ (p = 0.62) between HIV‐positive (20.3 ± 1.1 nmol/L, n = 238) and HIV‐negative subjects (19.3 ± 1.7 nmol/L, n = 121). The prevalence of vitamin D insufficiency (plasma 25(OH) vitamin D ≤ 37.5 nmol/L) was 87% (312/359). Dietary intake and summer/fall season were positive predictors of vitamin D status while race (black) and body mass index were negative predictors. The prevalence of vitamin D insufficiency in the REACH subjects was higher than expected based on previous work in adolescents and young adults. Limited sun exposure among these disadvantaged, largely urban subjects may be the cause of this disparity.