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Relationship between isoflavone intake and urinary excretion of isoflavones and their metabolites among Korean girls of pubertal age
Author(s) -
Kim HyeJin,
Paik Hee Young,
Song YoonJu,
Joung Hyojee,
Franke Adrian A.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a181-c
Subject(s) - daidzein , equol , glycitein , genistein , excretion , isoflavones , urine , creatinine , medicine , endocrinology , chemistry , urinary system
The aim of this study was to estimate the relationship between urinary isoflavone excretion and dietary isoflavone intake. Twenty‐four subjects were selected from a sample of 254 girls (8–11 y), twelve each from high and low isoflavone intake groups (n=2 x 12). The mean daily isoflavone intake of the high group using twice 3‐day dietary records was significantly higher than that of the low group (14.6mg/d vs 3.7mg/d, p<0.001). Two overnight urine samples were collected from each subject approximately six months apart and analyzed for excretion of isoflavones and their metabolites (daidzein, genistein, glycitein, equol, O‐desmethylangolensin, dihydrodaidzein and dihydrogenistein) by LC/MS. Urinary total isoflavone excretion of the high group was significantly higher than that of the low group (35.2nmol/mg creatinine vs 13.6nmol/mg creatinine, P<0.005). Total isoflavone excretion was positively correlated with mean daily intake of isoflavone (r=0.59; p<0.01). Urinary excretion of individual isoflavones and metabolites were correlated with isoflavone intake except genistein and dihydrogenistein (r= 0.41~0.55; p<0.05). This suggests that urinary isoflavone excretion can be used as a biomarker of soy/isoflavone intake in girls of pubertal age. Supported by grant from Korea Research Foundation (Project Number: C00079).