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Estimating whole‐body intermuscular adipose tissue from single cross‐sectional magnetic resonance images
Author(s) -
Ruan Xiangyan,
Gallagher Dympna,
Harris Tamara,
Albu Jeanine,
Heymsfield Steven,
Kuznia Patrick,
Heshka Stanley
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a165-a
Subject(s) - magnetic resonance imaging , adipose tissue , fascia , thigh , medicine , forearm , subcutaneous adipose tissue , anatomy , nuclear medicine , radiology
The aim of this study was to determine which slice location, or combination of slice locations, can provide the best estimates of whole‐body intermuscular adipose tissue (IMAT) and the predictive value of these slice locations. Whole body magnetic resonance imaging (MRI) was used to quantify total adipose tissue (TAT) of which IMAT, defined as the AT visible by MRI within the boundary of the muscle fascia, is a sub‐component. Single slice IMAT areas were calculated for widest calf, mid‐thigh, widest buttock, shoulders, mid‐upper arm, and mid‐forearm locations in a sample of healthy adult African American, Asian and Caucasian women (n=103; BMI 25.9±5.5 kg/m 2 ; 42.2±15.2 years) and Caucasian men (n=41; BMI 26.8±3.9 kg/m 2 ; 46.6±15.6 years) and used to estimate total IMAT in the different groups with regression equations.Mid‐thigh was the best, or near best, single predictor in all groups. The contributions of other slice locations varied by sex and race. It may be more cost‐effective to estimate IMAT based on one or more slices than to acquire and segment numerous images necessary to quantify whole‐body IMAT. This study was supported by DK42618; NIH AG14715, RR00645, DK40414; and a contract from the NIA.