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Expression of Transforming Growth Factor‐beta Receptors I and II on White Blood Cells in Ovarian Cancer Survivors
Author(s) -
Regisford E. Gloria C.,
KellyBrown Cordella,
Hajek Richard,
Schettino Maria
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a153
Subject(s) - ovarian cancer , medicine , transforming growth factor beta , endocrinology , receptor , cytokine , tgf beta signaling pathway , transforming growth factor , beta (programming language) , oncology , tgf beta 1 , white blood cell , cancer , andrology , computer science , programming language
Ovarian cancer has the highest mortality rate among gynecological malignancies in developed countries. Numerous reports have indicated that diet can affect the risk of ovarian cancer incidence and recurrence. The cytokine family of Transforming Growth Factor‐beta (TGF‐beta), has been reported to play conflicting roles in ovarian cancer cell growth. TGF‐beta is a growth regulator that affects multiple cellular functions through the TGF‐beta type I and II receptors (TGF‐beta RI and TGF‐beta RII). The objective of this study was to evaluate the effect of high fiber diets on the expression of TGF‐beta RI and TGF‐beta RII on white blood cells. Twenty patients, who had undergone conventional treatment for ovarian cancer were placed on either (1) an Intervention group‐NCI/Juice Plus+ diet (n=11) or (2) a Control group‐Women’s Healthy Eating Living Study (WHEL) diet (n=9) for six months. Blood samples were collected at the following time points: 0, 3 and 6 months. The expression levels of TGF‐beta RI and TGF‐beta RII on white blood cells were determined using Western Blot analysis. The expression of TGF‐beta RI and TGF‐beta RII increased over time in both groups of patients. However, the expression levels of both TGF‐beta RI and TGF‐beta RII were slightly higher in patients on the WHEL diet than in patients on the NCI/Juice Plus+ diet. These data suggest that a diet high in fiber may alter the expression pattern of TGF‐beta RI and TGF‐beta RII on white blood cells and may thus promote the activities of TGF‐beta in ovarian cancer survivors.