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C‐Reactive Protein (Crp), Lipid Profile, and Coronary Heart Disease (CHD) Risk in HIV+ Drug Users in Miami
Author(s) -
Rafie Carlin,
Campa Adriana,
Duan Rui,
Sales Sabrina,
Xue Lihua,
Rodriguez Patricia,
Baum Marianna K
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a148-c
Subject(s) - c reactive protein , coronary heart disease , human immunodeficiency virus (hiv) , miami , medicine , lipid profile , drug , cardiology , pharmacology , cholesterol , inflammation , virology , environmental science , soil science
Background CHD is increasing among HIV+ persons, due to the disease, use of HAART, length of survival, or a combination of these factors. Although lipid profiles are used in CHD risk screening, there is evidence for the predictive value of high‐sensitivity (hs) Crp levels for CHD. We examined the relationship of Crp to other CHD risk factors and acute phase reactants in HIV+ drug users. Methods After consenting 156 HIV+ drug users, blood was drawn for lipid profiles,(hs) Crp, CD4 count and viral load. Anthropometries, demographics, medical and antiretroviral treatment histories were completed. HDL was considered low for men ≤40 mg/dl, women ≤50 mg/dl. Results Of 156 cases, 65 (41.7%) had abnormal Crp (>3 mg/L), 16% showed high total cholesterol (≥200mg/dl), 46% high LDL (≥100 mg/dl), and 29% high triglycerides (≥150mg/dl). Median Crp was significantly higher in participants with low levels of HDL than in those within normal range [3.0 (0.12, 43.37) vs. 1.48 (0.10, 32.5), p = 0.011]. In multivariate analysis, high CRP was significantly associated with low HDL (OR=1.45; 95% CI:1.1,1.89; p=0.007), after controlling for gender, age, CD4 count, viral load, obesity, HAART, smoking and high blood pressure. Crp was not correlated with other lipid parameters. Crp was significantly and inversely correlated with acute phase reactants including albumin (r = −0.17, p = 0.04), hemoglobin (r = −0.21, p = 0.009) and plasma zinc (r = −0.21, p = 0.014). Conclusions The prevalence of elevated Crp in this cohort is higher than that of hyperlipidemia, independent of HAART, and may be a more sensitive marker of CHD risk. Further research into the role of Crp in HIV+ drug users is needed. Funded by NIDA