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Plasma adiponectin concentrations and correlates in African Americans in the HyperGEN Network Birmingham field center
Author(s) -
Shikany James,
Lewis Cora E.,
Freedman Barry I.,
LeiendeckerFoster Catherine,
Jones Tamekia L.,
Oberman Albert
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a148
Subject(s) - adiponectin , medicine , endocrinology , population , waist , type 2 diabetes , insulin resistance , diabetes mellitus , obesity , environmental health
Adiponectin is an adipocyte‐derived peptide which exhibits anti‐inflammatory, insulin‐sensitizing, and anti‐atherogenic properties. Hypoadiponectinemia has been observed in obesity, type 2 diabetes, hypertension, and coronary heart disease. Little is known about correlates of adiponectin in African Americans, a population at particular risk of these chronic diseases. Adiponectin concentrations and correlates were studied in 201 African‐American participants of the HyperGEN Network Birmingham field center who were non‐medicated offspring of hypertensives (87 males and 114 females; 18–55 years of age). Mean (± SD) plasma adiponectin concentration was 5.5 ± 3.8 μ g/mL (range: 0.9–24.7 μ g/mL). Concentrations varied by sex: 4.2 ± 2.5 μ g/mL in males and 6.5 ± 4.4 μ g/mL in females (p <0.0001). Log‐transformed values of adiponectin concentration were used in the analyses. In univariate analyses, adiponectin was negatively and significantly associated with BMI (Pearson r = −0.20), waist/hip ratio (r = −0.48), serum triglycerides (r = −0.31), creatinine (r = −0.28), uric acid (r = −0.34), glucose (r = −0.33), and insulin (r = −0.32). Adiponectin was positively and significantly associated with HDL‐C (r = 0.41). There was no association between adiponectin and age. Multiple linear regression modeling indicated that sex, waist/hip ratio, insulin, and HDL‐C were independently and significantly associated with adiponectin. Adiponectin is associated with multiple cardiovascular disease risk factors in African Americans.