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Effect of High Dose Alpha Tocopherol Therapy on Carotid Atherosclerosis, Biomarkers of Oxidative Stress and Inflammation in Patients with Coronary Artery Disease
Author(s) -
Devaraj Sridevi,
Tang Rong,
Huet Beverley,
Harris Andrea,
Sreenivasan Thanalakshmi,
Delemos James,
Jialal Ishwarlal
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a132-c
Subject(s) - medicine , placebo , oxidative stress , coronary artery disease , inflammation , isoprostane , gastroenterology , coronary atherosclerosis , cardiology , intima media thickness , c reactive protein , endocrinology , pathology , carotid arteries , lipid peroxidation , alternative medicine
Oxidative stress and inflammation are crucial in atherogenesis. High dose Alpha tocopherol (RRR‐AT) supplementation has antioxidant and anti‐inflammatory effects. Prospective studies with lower doses of AT on atherosclerosis have been equivocal. Thus, we tested the effect of RRR‐AT supplementation(1200 IU/day for 2 years)on carotid atherosclerosis in a placebo‐controlled, double blind study of 90 stable coronary artery disease patients. Intimal medial thickness (IMT) of both carotids, was determined by B‐mode sonography at 0, 1, 1.5 and 2 yrs. At 6‐month intervals blood was obtained for AT levels, C‐reactive protein (CRP) and 24‐hour urine for F2 ‐isoprostanes. AT levels significantly increased in the AT group (2.4‐fold) but not in placebo. There was no significant difference in total or left carotid IMT between placebo and AT groups. There was a significant increase in IMT progression in Placebo with time for total and right CCA‐IMT (p<0.05). Also, there was a significant decrease in IMT progression in the right CCA between placebo and AT groups over 2 years (p=0.017). HsCRP levels and F2‐isoprostane levels significantly decreased with AT therapy compared to placebo (32% and 26%,p<0.01). Thus, high dose RRR‐AT supplementation in CAD patients significantly reduced biomarkers of oxidative stress and inflammation, there was only a marginal benefit with regards to carotid atherosclerosis progression.