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The combination of psyllium (PSY) and plant sterol (PS) as a nutritional therapy improved plasma LDL cholesterol and glucose levels and resulted in a larger LDL particle
Author(s) -
Shrestha Sudeep,
Wood Richard J,
Greene Christine M,
Aggarwal Dimple,
Volek Jeff S,
Udani Jay,
Fernandez MariaLuz
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a125-c
Subject(s) - psyllium , placebo , medicine , cholesterol , endocrinology , chemistry , apolipoprotein b , zoology , sterol , ldl cholesterol , plantago ovata , washout , food science , dietary fiber , biology , botany , alternative medicine , pathology
A randomized, double blind, cross‐over, placebo controlled study was conducted to determine the effects of plant sterol and soluble fiber provided via cookies on plasma lipids, LDL mean size and plasma glucose. 33 healthy free living individuals (11males and 22 females) aged 35–65 y with a BMI between 25–35 kg/m 2 and initial plasma LDL cholesterol (LDL‐C) concentrations between 100–160 mg/dL were randomly assigned into treatment [7.68 g of psyllium (PSY) and 2.6 g plant sterol (PS)] or placebo cookies for 4 wk. Subjects were advised to continue their normal dietary intake and level of activity during the 11 week‐intervention. After a 3‐wk washout period, subjects crossed over to the alternate cookie for an additional 4 wk. Plasma total cholesterol concentrations were significantly reduced from 220.8 ± 30.2 mg/dL during the placebo to 201.9 ± 27.3 mg/dL during the PSY‐PS cookie period (P < 0.01). These reductions were associated with LDL‐C, which decreased from 134.7 ± 28.1 to 118.2 ± 26.7 mg/dL following PSY‐PS cookie consumption (P < 0.001). Intake of the PSY‐PS cookie resulted in an increase in LDL mean diameter (27.11 ± 0.37 nm) compared to the placebo cookie (27.00 ± 0.40 nm), (P < 0.05). In addition, blood glucose levels were lower following intake of the PSY‐SP cookie (91.4 ± 9.6 mg/dL) compared to placebo (94.9 ± 8.4) (P< 0.05). No significant differences in HDL‐C or triglycerides were observed. These results indicate that the cookie enriched with PSY and PS was effective in reducing several risk factors for coronary heart disease.