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Cofactors in and as posttranslational protein modifications
Author(s) -
Rucker Robert B.,
Wold Finn
Publication year - 1988
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2.7.3127264
Subject(s) - posttranslational modification , cofactor , chemistry , microbiology and biotechnology , biochemistry , computational biology , biology , enzyme
A symposium at the FASEB meeting in Las Vegas in May 1988 will be devoted to the role of cofactors (vitamins, coenzymes, prosthetic groups) in and as posttranslational protein modifications; the symposium is part of a thematic focus on metabolic regulation. In planning the symposium, we decided to consider metabolic regulation in its broadest context, which should include both the short‐term activity modulations in the life of contemporary organisms and the adaptations of special molecular strategies over evolutionary time. We further decided to focus the symposium context on the involvement of cofactors both as catalytic partipicants in and as substrates or end products of posttranslational modifications. As a preview of the actual symposium, the present discussion is an attempt to enumerate cases of cofactor involvement in these different categories: 1 ) essential nutrients as participants in posttranslational modifications; 2 ) cofactors as donor substrates in reversible, regulatory modifications; and 3 ) cofactor incorporation or generation as covalent constituents of proteins. The actual symposium topics are taken from category 1 : vitamin C and protein hydroxylation (K. I. Karivikkio) and vitamin K and protein carboxylation (J. W. Suttie) and category 3: biotinylation (H. G. Wood), phycobiliproteins (A. Glazer), and pyruvoyl enzymes (W. Dowhan).— R ucker , R. B.; W old , F. Cofactors in and as posttranslational protein modifications. FASEB J. 2: 2252‐2261; 1988.