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Bile acid synthesis: down‐regulation by monohydroxy bile acids 1
Author(s) -
Hall Roberta,
Kok Engeline,
Javitt Norman B.
Publication year - 1988
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2.2.3342968
Subject(s) - lithocholic acid , glycocholic acid , chenodeoxycholic acid , bile acid , cholic acid , deoxycholic acid , enterohepatic circulation , chemistry , medicine , taurocholic acid , biochemistry
The regulation of bile acid synthesis was studied in rabbits after interruption of the enterohepatic circulation by choledochoureteral anastomosis. Total daily bile acid output was 772 ± 130 (SD) μmol/24 h, of which > 95% was glycocholic acid. Administration of deoxycholic or cholic acid or their conjugates (300‐800 μmol) or gallbladder bile failed to down‐regulate endogenous bile acid synthesis. In contrast, chenodeoxycholic acid administration did down‐regulate bile acid synthesis, but this effect was related to the formation and excretion of lithocholic acid. This observation was confirmed by the finding that i.v. infusion of 10‐20 μmol of either lithocholic acid or 3β‐hydroxy‐5‐cholenoic acid significantly reduced cholic acid synthesis. Thus monohydroxy bile acids, derived from either hepatic or intestinal sources, participate in the down‐regulation of bile acid synthesis.— H all , R.; K ok , E.; J avitt , N. B. Bile acid synthesis: down‐regulation by monohydroxy bile acids. FASEB J. 2: 152‐156; 1988.