Premium
Identification of N ‐(2‐propenal) serine as a urinary metabolite of malondialdehyde
Author(s) -
Hadley Mary,
Draper H. H.
Publication year - 1988
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2.2.3125082
Subject(s) - malondialdehyde , metabolite , chemistry , lipid peroxidation , serine , urine , biochemistry , urinary system , oxidative stress , enzyme , endocrinology , biology
N ‐2‐(Propenal) serine (S‐MDA) was synthesized by reacting serine with malondialdehyde (MDA) and was shown to be a 1:1 adduct of the starting materials. The synthetic compound was found to be identical to a metabolite of MDA excreted in rat and human urine. The identity of the metabolite was confirmed by isolation and hydrolysis to yield equimolar quantities of serine and MDA. The presence of S‐MDA in urine constitutes direct evidence for oxidative decomposition of phospholipids by lipid peroxidation in vivo.— H adley , M.; D raper , H. H. Identification of N ‐(2‐propenal) serine as a urinary metabolite of malondialdehyde. FASEB J. 2: 138‐140; 1988.