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In vitro cytocidal effect of novel lytic peptides on Plasmodium falciparum and Trypanosoma cruzi 1
Author(s) -
Jaynes Jesse M.,
Burton Catherine A.,
Barr Stephen B.,
Jeffers Gale W.,
Julian Gordon R.,
White Kenneth L.,
Enright Fred M.,
Klei Thomas R.,
Laine Roger A.
Publication year - 1988
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2.13.3049204
Subject(s) - trypanosoma cruzi , lytic cycle , plasmodium falciparum , in vitro , vero cell , virology , biology , microbiology and biotechnology , chagas disease , parasite hosting , protozoa , protozoan parasite , immunology , virus , malaria , biochemistry , world wide web , computer science
Plasmodium falciparum and Trypanosoma cruzi were killed by two novel lytic peptides (SB‐37 and Shiva‐1) in vitro. Human erythrocytes infected with P. falciparum , and Vero cells infected with T. cruzi , were exposed to these peptides. The result, in both cases, was a significant decrease in the level of parasite infection. Furthermore, the peptides had a marked cytocidal effect on trypomastigote stages of T cruzi in media, whereas host eukaryotic cells were unaffected by the treatments. In view of the worldwide prevalence of these protozoan diseases and the lack of completely suitable treatments, lytic peptides may provide new and unique chemother‐apeutic agents for the treatment of these infections.—J aynes , J. M.; B urton , C. A.; B arr , S. B.; J effers , G. W.; J ulian , G. R.; W hite , K. L.; E nright , F. M.; K lei , T. R.; L aine , R. A. In vitro cytocidal effect of novel lytic peptides on Plasmodium falciparum and Trypanosoma cruzi. FASEB J. 2: 2878‐2883; 1988.