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Oxidants, inflammation, and anti‐inflammatory drugs
Author(s) -
Halliwell Barry,
Hoult J. Robin,
Blake David R.
Publication year - 1988
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2.13.2844616
Subject(s) - hypochlorous acid , in vivo , inflammation , chemistry , hydroxyl radical , hydrogen peroxide , anti inflammatory , superoxide , pharmacology , rheumatoid arthritis , arthritis , reactive oxygen species , medicine , biochemistry , antioxidant , immunology , enzyme , biology , microbiology and biotechnology
Species such as superoxide radical (O 2 − ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical ( · OH), and hypochlorous acid (HOC1) can be formed in vivo, e.g., by activated phagocytic cells. Generation of · OH from H 2 O 2 in vivo usually involves iron‐dependent reactions. Good evidence exists for increased generation of oxidants in vivo in patients with active rheumatoid disease, but the contribution of these oxidants to the disease process is still uncertain. The likelihood that anti‐inflammatory drugs used in the treatment of arthritis could act by scavenging oxidants or preventing their formation is discussed.— H alliwell , B.; H oult , J. R.; B lake , D. R. Oxidants, inflammation, and anti‐inflammatory drugs. FASEB J. 2: 2867‐2873; 1988.