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P‐glycoprotein‐overexpressing multidrug‐resistant cells are resistant to infection by enveloped viruses that enter via the plasma membrane 1
Author(s) -
RAVIV YOSSEF,
PURI ANU,
BLUMENTHAL ROBERT
Publication year - 2000
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.14.3.511
Subject(s) - viral envelope , virology , multiple drug resistance , virus , biology , lipid bilayer fusion , glycoprotein , herpes simplex virus , hemagglutinin (influenza) , herpesvirus glycoprotein b , viral entry , drug resistance , microbiology and biotechnology , viral replication
The multidrug resistance gene product P‐glycoprotein confers drug resistance to tumor cells by acting as a transporter that blocks the entry into the cell of a great variety of drugs and hydrophobic pep‐tides. In this study we find that in drug‐resistant cells, the insertion of the influenza virus fusion protein (hemagglutinin‐2) into the plasma membrane is blocked and that the fusion of the viral envelope with the plasma membrane of these cells is impaired. Mul‐tidrug‐resistant cells display significant resistance to infection by envelope viruses that invade cells by fusion with the plasma membrane, but not to infection by pH‐dependent viruses that penetrate cells by fusion with endocytic vesicles. These observations suggest that multidrug resistance phenomena may protect cells from infection by a large group of disease‐causing viruses that includes human immunodeficiency virus, herpes simplex virus, and some cancer‐inducing retro‐viruses.—Raviv, Y., Puri, A., Blumenthal, R. P‐glycoprotein‐overexpressing multidrug‐resistant cells are resistant to infection by enveloped viruses that enter via the plasma membrane. FASEB J. 14, 511–515 (2000)