Premium
RNA sorting in Xenopus oocytes and embryos
Author(s) -
Mowry Kimberly L.,
Cote Colette A.
Publication year - 1999
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.13.3.435
Subject(s) - xenopus , microbiology and biotechnology , biology , polarity in embryogenesis , polarity (international relations) , embryo , somatic cell , messenger rna , rna , cytoplasm , embryonic stem cell , gene , embryogenesis , genetics , cell , gastrulation
ABSTRACT Cytoplasmic localization of mRNA molecules has emerged as a powerful mechanism for generating spatially restricted gene expression. This process is an important contributor to cell polarity in both somatic cells and oocytes, and can provide the basis for patterning during embryonic development. In vertebrates, this phenomenon is perhaps best documented in the frog, Xenopus laevis , where polarity along the animal‐vegetal axis coincides with the localization of numerous mRNA molecules. Research over the last several years has made exciting progress toward understanding the molecular mechanisms underlying cytoplasmic mRNA localization.— Mowry, K. L., Cote, C. A. RNA sorting in Xenopus oocytes and embryos. FASEB J. 13, 435–445 (1999)