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Role of single‐stranded DNA regions and Y‐box proteins in transcriptional regulation of viral and cellular genes
Author(s) -
Swamynathan S. K.,
Nambiar Ashok,
Guntaka Ramareddy V.
Publication year - 1998
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.12.7.515
Subject(s) - promoter , gene , dna , transcription (linguistics) , biology , dna binding protein , transcription factor , genetics , dna binding site , computational biology , microbiology and biotechnology , gene expression , linguistics , philosophy
Single‐stranded regions, known to be important for optimal rates of transcription, have been observed in the promoters of several cellular genes as well as in the promoters of many pathogenic viruses. Several host‐encoded, single‐stranded DNA binding proteins capable of binding these regions have been purified and their genes isolated. In this review, information available about single‐stranded regions present within various promoters and the interaction of a novel class of single‐stranded DNA binding transcription factors belonging to the Y‐box family of proteins is reviewed. Mechanisms by which these proteins influence transcription of both cellular and viral genes are proposed.