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A synthetic model of intra‐Golgi traffic
Author(s) -
Mironov Alexander,
Luini Alberto,
Mironov Alexander
Publication year - 1998
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.12.2.249
Subject(s) - golgi apparatus , microbiology and biotechnology , vesicle , secretory pathway , secretory vesicle , axoplasmic transport , membrane transport , copi , computer science , chemistry , membrane , biology , biochemistry , endoplasmic reticulum
We present a hypothesis on the mechanisms used by cells to transport cargo through the secretory system. We propose that at least three basic processes coordinately participate in membrane traffic: cisternal maturation–progression, controlled cargo diffusion along transient membrane continuities between different compartments, and a mostly retrograde vesicle‐mediated transport. A ‘synthetic’ model based on the combination of these mechanisms can explain both the progression of supramolecular aggregates through the secretory pathway and the fast intra‐Golgi transport of conventional cargoes. Analysis of the existing literature shows that the available data are consistent with the proposed model.—Mironov, A., Jr., Luini, A., Mironov, A. A synthetic model of intra‐Golgi traffic. FASEB J. 12, 249–252 (1998)