Premium
Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus
Author(s) -
Costa Cristina,
Solanes Gemma,
Visa Joana,
Bosch Fatima
Publication year - 1998
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.12.14.1455
Subject(s) - acromegaly , medicine , endocrinology , hyperinsulinemia , hypertriglyceridemia , insulin resistance , growth hormone receptor , diabetes mellitus , kidney , transgene , fibrosis , hyperinsulinism , hormone , growth hormone , biology , cholesterol , triglyceride , gene , biochemistry
Transgenic rabbits expressing the bovine growth hormone (bGH) gene in liver and kidney were obtained to study the long‐term effects of chronic exposure to GH in nonrodent animals. These rabbits presented high levels of bGH and insulin‐like growth factor I in serum. In spite of chronic exposure to bGH, transgenic rabbits had similar body weight to controls. However, enlargement of the head and limbs and reduction of visceral fat were observed in these animals. They also showed marked hyperinsulinemia, hyperglycemia, and hypertriglyceridemia, indicating that they developed insulin resistance. Furthermore, serious histopathological alterations, including marked fibrosis, were observed in liver, kidney, and skeletal muscle. These anatomical, metabolic, and histological alterations closely resemble those found in patients with acromegaly. Thus, transgenic rabbits overexpressing GH may be a good model of the human disease.—Costa, C., Solanes, G., Visa, J., Bosch, F. Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus. FASEB J. 12, 1455–1460 (1998)