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Expression of the multidrug resistance genes in the liver
Author(s) -
Silverman Jeffrey A.,
Schrenk Dieter
Publication year - 1997
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.11.5.9141496
Subject(s) - transporter , p glycoprotein , atp binding cassette transporter , multiple drug resistance , gene , xenobiotic , biology , abcc1 , multidrug resistance associated proteins , biochemistry , gene expression , membrane transport protein , efflux , microbiology and biotechnology , enzyme , antibiotics
The liver is presented with a diverse set of nutrients, endogenous metabolites, and xe‐nobiotics it must process for movement to their correct physiologic destinations. These compounds are transported by specific mechanisms that move their substrates, often against a concentration gradient. Several hepatic transporters have been identified such as the multispecific anion transporter, cMOAT, bile acid transporters, ion‐motive ATPases, gluta‐thione transporters, purine transporters, and the multidrug resistance‐related protein, MRP. This review focuses on the hepatic regulation of the multidrug resistance genes that encode the P‐gly‐coprotein transporters. P‐glycoproteins are ATP‐dependent integral membrane proteins that have diverse functions such as conferring resistance toward chemotherapeutic drugs and phospholipid movement. The expression of the multidrug resistance genes is regulated in a tissue‐specific pattern and can be induced by exposure to chemotherapeutic drugs as well as cytotoxic xenobiotics. The specific molecular mechanisms that govern expression of these genes in normal and neoplastic cells are currently being unraveled.—Silverman, J. A., Schrenk, D. Expression of the multidrug resistance genes in the liver. FASEB J. 11, 308‐313 (1997)