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Retinoic aid increases arrestin mRNA levels in the mouse retina
Author(s) -
Wagner Elisabeth,
McCaffery Peter,
Mey Jörg,
Farhangfar Farhang,
Applebury Meredithe L.,
Dräger Ursula C.
Publication year - 1997
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.11.4.9068616
Subject(s) - retinoic acid , messenger rna , arrestin , retina , biology , microbiology and biotechnology , retinal , chemistry , signal transduction , endocrinology , biochemistry , gene , neuroscience , g protein coupled receptor
Arrestin, which plays a role in the termination of the visual transduction cascade, is one of several photoreceptor proteins whose mRNA levels are increased by light. Retinoic acid, a by‐product of photoreceptor signaling and a potent modulator of hormonal transcription control, is one candidate for regulating the arrestin mRNA levels. Here we show that retinoic acid, injected intraperi‐toneally into dark‐adapted mice, increases the arrestin mRNA levels and mimics the effect of light. Injection of 1 μmol of retinoic acid produces a maximal increase in arrestin mRNA levels. The mRNA level reaches a maximum 3 h after injection and slowly declines thereafter. The observations suggest that retinoic acid may mediate the increase in arrestin mRNA produced by light.—Wagner, E., McCaffery, P., Mey, J., Farhangfar, F., Applebury, M. L., Dräger, U. C. Retinoic aid increases arrestin mRNA levels in the mouse retina. FASEB J. 11, 271‐275 (1997)