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Journey from cachexia to obesity by TNF
Author(s) -
Argilés Josep M.,
LópezSoriano Joaquín,
Busquets Sílvia,
LópezSoriano Francisco J.
Publication year - 1997
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.11.10.9271359
Subject(s) - cachexia , tumor necrosis factor alpha , obesity , adipose tissue , cytokine , medicine , endocrinology , cancer
Tumor necrosis factor‐α (TNF‐α) is a cytokine involved in the physiological and metabolic abnormalities found in cachectic states. Until very recently, it was inconceivable to think of TNF‐α in obesity. However, recent studies have shown that TNF‐α can also play a key role in obesity, the cytokine being overexpressed in adipose tissue of obese rodents and humans. The aim of this review is to reconcile the role of TNF‐α in these two opposite metabolic situations: obesity and cachexia. It is suggested that TNF‐α may have a key role in the control of body mass in normal weight‐controlled situations and that abnormalities in either its production (during cachexia) or action (during obesity) are responsible for the lack of control of body weight.—Argilés, J. M., López‐Soriano, J., Busquets, S., López‐Soriano, F. J. Journey from cachexia to obesity by TNF. FASEB J. 11, 743–751 (1997)