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Molecular mechanisms of retinoid actions in skin
Author(s) -
Fisher Gary J.,
Voorhees John J.
Publication year - 1996
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.10.9.8801161
Subject(s) - retinoid , retinoic acid , hypervitaminosis , hypervitaminosis a , retinoid x receptor , biology , function (biology) , nuclear receptor , vitamin , microbiology and biotechnology , retinol , neuroscience , biochemistry , transcription factor , gene
For more than 40 years, it has been appreciated that vitamin A is a critical regulator of growth and differentiation of developing and adult mammalian and avian skin. Vitamin A deficiency and hypervitaminosis A cause disruption of normal cellular homeostatic mechanisms, resulting in impairment of skin barrier function. More recent studies demonstrating all‐trans retinoic acid as the major biologically active form of vitamin A, and nuclear retinoid receptors as the major mediators of all‐trans retinoic acid actions, have provided exciting new insights into the molecular basis of vitamin A actions. These recent insights have been the driving force for important advances in the many areas of retinoid research made during the past 6 years. Nowhere has this new knowledge been more extensively applied than toward understanding the molecular basis of retinoid physiology and pharmacology in skin. This article will review these recent findings and attempt to synthesize their meaning to provide a view into the mechanisms whereby retinoids participate in regulation of skin function.—Fisher, G. J., Voorhees, J. J. Molecular mechanisms of retinoid actions in skin. FASEBJ. 10,1002‐1013 (1996)