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Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function
Author(s) -
Iozzo Renato V.,
Murdoch Alan D.
Publication year - 1996
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.10.5.8621059
Subject(s) - leucine rich repeat , extracellular , gene , glycoprotein , gene family , function (biology) , proteoglycan , biology , extracellular matrix , microbiology and biotechnology , biochemistry , chemistry , genetics , gene expression
This review focuses on the extracellular proteoglycans. Special emphasis is placed on the structural features of their protein cores, their gene organization, and their transcriptional control. A simplified nomenclature comprising two broad groups of extracellular proteoglycans is offered: the small leucine‐rich proteoglycans or SLRPs, pronounced “slurps,” and the modular proteoglycans. The first group encompasses at least five distinct members of a gene family characterized by a central domain composed of leucine‐rich repeats flanked by two cysteine‐rich regions. The second group consists of those proteoglycans whose unifying feature is the assembly of various protein modules in a relatively elongated and often highly glycosylated structure. This group is quite heterogeneous and includes a distinct family of proteoglycans, the “hyalectans,” that bind hyaluronan and contain a C‐type lectin motif that is likely to bind carbohydrates, and a less distinct group that contains structural homologies but lacks hyaluronan‐binding properties or lectin‐like domains.—Iozzo, R. V., Murdoch, A. D. Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. FASEB J . 10, 598‐614 (1996)