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The role of proteases during apoptosis
Author(s) -
Patel Tushar,
Gores Gregory J.,
Kaufmann Scott H.
Publication year - 1996
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.10.5.8621058
Subject(s) - proteases , apoptosis , protease , pathogenesis , microbiology and biotechnology , biology , enzyme , biochemistry , immunology
The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.—Patel, T., Gores, G. J., Kaufmann, S. H. The role of proteases during apoptosis. FASEB J. 10, 587‐597 (1996)