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Regulation of signal transduction during liver regeneration
Author(s) -
Diehl A. M.,
Rai R. M.
Publication year - 1996
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.10.2.8641555
Subject(s) - liver regeneration , hepatocyte , biology , microbiology and biotechnology , regeneration (biology) , phenotype , signal transduction , hepatectomy , obligate , intracellular , gene , medicine , resection , in vitro , genetics , ecology , surgery
The liver has a tremendous capacity to regenerate. For example, after extensive hepatic resection, remaining hepatocytes proliferate to restore the mass of the organ within days to weeks. This proliferative response is fascinating because hepato‐cyles rarely replicate in the healthy adult liver. Instead, these cells perform highly specialized functions and exemplify mature, terminally differentiated cells.Therefore it is somewhat surprising that the liver can repopulate while performing its many obligate., organ‐specific functions. Study of the regenerating liver remnant after partial hepatectomy has helped to delineate mechanisms that regulate proliferation and liver‐specific functions in individual hepatocytes, as well as those that coordinate the behaviors of different liver cell populations to balance organ growth and tissue‐specific gene expression. Hence, this review will focus on inter‐ and intracellular signals that regulate the hepatocyte phe‐notype after PH.—Diehl, A. M., Rai, R. M., Regulation of signal transduction during Liver regeneration. FASEB J. 10, 215‐227 (1996)