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Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application
Author(s) -
Robinson Michael B.,
Coyle Joseph T.
Publication year - 1987
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.1.6.2890549
Subject(s) - excitatory postsynaptic potential , glutamate receptor , neuroscience , excitatory synapse , chemistry , pharmacology , neuroprotection , excitatory amino acid transporter , excitatory amino acid antagonists , receptor , biology , biochemistry
There is convincing evidence that acidic amino acids, in particular l ‐glutamate, or substances containing them serve as the major excitatory neurotransmitters in the brain. At least three distinct receptors mediate the excitatory effects of this class of neurotransmitters. Pharmacological studies with agonists and antagonists of these receptors suggest that they may mediate the neurodegenerative consequences of Huntington's disease, status epilepticus, and hypoxemia, and that glutamate receptor antagonists have clinical potential as anticonvulsants, analgesics, and neuroprotective agents.— R obinson , M. B.; C oyle , J. T. Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application. FASEB J. 1: 446‐455; 1987.