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Inhibition of induced acute lung edema by a novel protein kinase C inhibitor
Author(s) -
Struhar David,
Harbeck Ronald J.
Publication year - 1987
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.1.2.3609609
Subject(s) - albumin , protein kinase c , pulmonary edema , edema , lung , phorbol , leak , chemistry , medicine , endocrinology , enzyme , pharmacology , biochemistry , environmental engineering , engineering
The effect of the protein kinase C enzyme inhibitor H‐7 on the noncardiogenic lung edema induced by phorbol myristate acetate (PMA) in mice was examined. Lung edema was assessed by measurement of 125 I‐labeled albumin leak into the lung. The results showed that pretreatment of mice with H‐7 nearly prevents the albumin leak induced by PMA, whereas post‐PMA treatment with H‐7 had less of an effect on the albumin leak, although it was still significant.— S truhar , D.; H arbeck , R. J. Inhibition of induced acute lung edema by a novel protein kinase C inhibitor. FASEB J. 1: 116‐118; 1987.