Premium
Potent Natural Immunomodulator, Rice Water‐Soluble Polysaccharide Fractions with Anticomplementary Activity
Author(s) -
Yamagishi Tatsunori,
Tsuboi Takuma,
Kikuchi Koichi
Publication year - 2003
Publication title -
cereal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.558
H-Index - 100
eISSN - 1943-3638
pISSN - 0009-0352
DOI - 10.1094/cchem.2003.80.1.5
Subject(s) - chemistry , polysaccharide , bran , biochemistry , protease , ferulic acid , moiety , saponin , polyphenol , food science , organic chemistry , enzyme , antioxidant , medicine , raw material , alternative medicine , pathology
Water‐soluble polysaccharide fractions, fractionated with ammonium sulfate from the hot‐water‐extract of rice bran and endosperm, showed a potent anticomplementary activity. As compared with water‐soluble polysaccharide isolated from Angelica acutiloba , which is a well‐known medicinal herb, the rice fractions showed similar or higher potency. Protease digestion, periodate oxidation, and hydroxylamine treatments indicated that anticomplementary activity is due to polysaccharide moiety rather than protein moiety and the polyphenol moieties, ferulic acid, being an integral component in rice bran proteoglycan. These results suggest that a water‐soluble proteoglycan and a polysaccharide in rice modulate complement activity. This is a new example of natural biological response modifiers in food.