Open AccessContribution ofSchistosoma mansonito systemic inflammation and microbial translocation among people with HIV in Zambia
Author(s) -
Briana D. Furch,
Simutanyi Mwakamui,
Sandie Siago,
Kanekwa Zyambo,
Douglas C. Heimburger,
John R. Koethe,
Paul Kelly
Publication year - 2021
Publication title -
transactions of the royal society of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 105
eISSN - 1878-3503
pISSN - 0035-9203
DOI - 10.1093/trstmh/trab103
Subject(s) - schistosoma mansoni , coinfection , schistosomiasis , immunology , serology , schistosoma , systemic inflammation , antibody , medicine , inflammation , biology , human immunodeficiency virus (hiv) , helminths
Schistosoma mansoni is hyperendemic in many rural areas of Zambia where up to 77% of people are positive for infection via serologic evaluation. Zambia also has a high prevalence of HIV infection. Individually, S. mansoni and HIV infection impair gastrointestinal barrier integrity and induce inflammation, but the effects of coinfection are not well understood. We set out to test the hypothesis that HIV would exacerbate intestinal barrier failure in patients with S. mansoni infection.