z-logo
open-access-imgOpen Access
Hemodynamic Response Function in Brain White Matter in a Resting State
Author(s) -
Ting Wang,
D.M. Wilkes,
Muwei Li,
Xi Wu,
John C. Gore,
Zhaohua Ding
Publication year - 2020
Publication title -
cerebral cortex communications
Language(s) - English
Resource type - Journals
ISSN - 2632-7376
DOI - 10.1093/texcom/tgaa056
Subject(s) - white matter , resting state fmri , state of matter , gray (unit) , neuroscience , physics , psychology , medicine , magnetic resonance imaging , nuclear medicine , radiology , condensed matter physics
Abstract The hemodynamic response function (HRF) characterizes temporal variations of blood oxygenation level-dependent (BOLD) signals. Although a variety of HRF models have been proposed for gray matter responses to functional demands, few studies have investigated HRF profiles in white matter particularly under resting conditions. In the present work we quantified the nature of the HRFs that are embedded in resting state BOLD signals in white matter, and which modulate the temporal fluctuations of baseline signals. We demonstrate that resting state HRFs in white matter could be derived by referencing to intrinsic avalanches in gray matter activities, and the derived white matter HRFs had reduced peak amplitudes and delayed peak times as compared with those in gray matter. Distributions of the time delays and correlation profiles in white matter depend on gray matter activities as well as white matter tract distributions, indicating that resting state BOLD signals in white matter encode neural activities associated with those of gray matter. This is the first investigation of derivations and characterizations of resting state HRFs in white matter and their relations to gray matter activities. Findings from this work have important implications for analysis of BOLD signals in the brain.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here