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Long-term exposure to pandemics like COVID-19 may increase psychological distress (e.g., peri-traumatic and post-traumatic distress) and sleep problems. Little is known about the effects of COVID-19 on peritraumatic distress, a well-documented risk factor for post-traumatic stress disorders (PTSD). The aim of this study was to investigate the association between COVID-19 risk perception and peritraumatic distress, and whether this relationship is moderated by sleep quality among individuals located in NY. Methods We examined data from 541 individuals (69% were female, mean age (SD) = 40.9 (15.3)] recruited online during summer and fall 2020 in New York for the NYU-COVID-19 Mental Health Study. Data were gathered on sociodemographic, COVID-19 risk perception (yes or no items), peri-traumatic distress measured by Peritraumatic Distress Inventory (PDI), and sleep quality measured by the Pittsburg Sleep Quality Index (PSQI). Descriptive, regression analysis and interaction terms were conducted using SPSS v. 25 to examine associations between COVID-19 risk perception with symptoms of peritraumatic distress and sleep quality. Results Of the 541 participants, 311(57.5%) reported they felt at risk for contracting COVID-19. PSQI was positively correlated with PDI (r =.38, p =0.01). An independent sample t student test indicated, on average, that the symptoms of PDI [(mean (SD)=27.3 (7.63), t = 7.07, n =307)] and PSQI [mean(SD)=10.62(3.57), t=4.31 n=311)] of our participants who felt at risk for contracting the COVID-19 significantly exceeded those who did not [(PDI mean(SD)=22.7(7.13), n =228); PSQI (mean(SD) =9.25(3.72), n=229]. Results of multiple linear regression analysis shown that COVID-19 risk perception was the strongest predictor of PDI [B(t) = −.630(12.7); p &amp;lt; .001]. Furthermore, the interaction effect of PSQI scores and COVID-19 risk perception revealed that sleep quality significantly reduced the association between COVID-19 risk perception and PDI [B(t) = .319(5.71); p &amp;lt;.001], such that poorer sleep and feeling at risk of contracting COVID-19 resulted in more severe PDI scores. Conclusion COVID-19 risk perception was associated with peritraumatic distress and poorer sleep quality, and sleep quality attenuated this relationship. Support (if any) NIH (T32HL129953, K07AG052685, R01MD007716, R01HL142066, K01HL135452, R01HL152453)

712 COVID-19 Risk Perception, Sleep Health and Peritraumatic Distress Among New Yorkers: The NYU COVID-19 Mental Health Study