Open AccessF67. NEUROCOGNITION IN 7-YEAR-OLD CHILDREN OF PARENTS WITH SCHIZOPHRENIA OR BIPOLAR DISORDER
Author(s) -
Nicoline Hemager,
Kerstin von Plessen,
Anne Thorup,
Camilla Jerlang Christiani,
Ditte Ellersgaard,
Katrine Søborg Spang,
Birgitte Klee Burton,
Aja Greve,
Ditte Lou Gantriis,
Anne Søndergaard,
Maja Gregersen,
Ole Mors,
Merete Nordentoft,
Jens Richardt Møllegaard Jepsen
Publication year - 2018
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1701
pISSN - 0586-7614
DOI - 10.1093/schbul/sby017.598
Subject(s) - neurocognitive , bipolar disorder , schizophrenia (object oriented programming) , offspring , psychology , psychiatry , psychosis , endophenotype , prepulse inhibition , cognition , clinical psychology , pregnancy , biology , genetics
Background Children of parents with schizophrenia or bipolar disorder display neurocognitive deficits. However, studies of schizophrenia offspring and bipolar offspring at the same age are lacking. The objective was to compare neurocognitive abilities in 7-year-old children of parents with schizophrenia or bipolar disorder with neurocognitive abilities in children of parents without these disorders. Methods In this nationwide cohort study we assessed 522 7-year-old children (schizophrenia offspring: N=202, bipolar offspring: N=120, and controls=200) with a detailed and well validated neurocognitive test battery. We compared the neurocognitive test scores of the three study groups. Results Children of parents with schizophrenia showed neurocognitive deficits, whereas children of parents with bipolar disorder displayed neurocognitive abilities comparable to the control group. Discussion Neurocognitive deficits are numerous in 7-year-old children of parents with schizophrenia, which supports the neurodevelopmental model of schizophrenia. Unimpaired neurocognitive abilities in children of parents with bipolar disorder indicate different neurodevelopmental manifestations in these high risk populations at this early age. Our results call for early identification of schizophrenia offspring with cognitive dysfunctions.