Placebo Response in Trials of Negative Symptoms in Schizophrenia: A Critical Reassessment of the Evidence | Zendy

Pál Czobor | Zendy; Brigitta Kakuszi | Zendy; István Bitter | Zendy

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Placebo Response in Trials of Negative Symptoms in Schizophrenia: A Critical Reassessment of the Evidence

Author(s) -

Pál Czobor,

Brigitta Kakuszi,

István Bitter

Publication year - 2022

Publication title -

schizophrenia bulletin

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.823

H-Index - 190

eISSN - 1745-1707

pISSN - 0586-7614

DOI - 10.1093/schbul/sbac061

Subject(s) - placebo , meta analysis , schizophrenia (object oriented programming) , placebo response , medicine , randomized controlled trial , clinical trial , meta regression , strictly standardized mean difference , psychiatry , pathology , alternative medicine

Summarizing evidence from clinical trials of patients with schizophrenia with predominant or prominent negative symptoms (NS), a prior meta-analysis reported a large placebo effect in negative symptoms (Cohen's d = 2.909). Assuming that such an effect was clinically not plausible, we performed a critical re-assessment and an update of the previous results with newly available data from add-on and monotherapy studies.

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