Open AccessAxonal dysfunction is associated with interferon-γ levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study
Author(s) -
Renan Bazuco Frittoli,
Danilo Florentino Pereira,
Aline Tamires Lapa,
Mariana Postal,
Nailú Angélica Sinicato,
Paula Teíxeira Fernándes,
Fernando Cendes,
Gabriela Castellano,
Letícia Rittner,
Roberto Marini,
Timothy B. Niewold,
Simone Appenzeller
Publication year - 2021
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/keab530
Subject(s) - medicine , creatine , odds ratio , gastroenterology , choline , corpus callosum , magnetic resonance imaging , endocrinology , pathology , radiology
Axonal/neuronal damage has been shown to be a pathological finding that precedes neuropsychiatric manifestations in SLE. The objective of this study was to determine the presence of axonal dysfunction in childhood-onset SLE patients (cSLE) and to determine clinical, immunological and treatment features associated with its occurrence.