Open AccessSolving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression
Author(s) -
Krizia Pocino,
Cecilia Napodano,
Laura Gragnani,
Gabriele Ciasca,
Stefania Colantuono,
Silvia Marri,
Lorenzo Vantaggio,
Francesca Gulli,
Serena Lorini,
Angelina Barini,
Annunziata Stefanile,
Luca Miele,
Milvia Casato,
Anna Linda Zignego,
Gian Ludovico Rapaccini,
Mariapaola Marino,
Marcella Visentini,
Umberto Basile
Publication year - 2021
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/keab157
Subject(s) - medicine , cryoglobulinemia , cryoglobulins , immunology , hepatitis b , liver disease , antibody , gastroenterology , hepatitis c virus , virus
The biomarkers of an immunological dysregulation due to a chronic HBV infection are indeed understudied. If untreated, this condition may evolve into liver impairment co-occurring with extrahepatic involvements. Here, we aim to identify a new panel of biomarkers [including immunoglobulin G (IgG) subclasses, RF, and Free Light Chains (FLCs)] that may be useful and reliable for clinical evaluation of HBV-related cryoglobulinemia.