Open AccessSub-setting systemic lupus erythematosus by combined molecular phenotypes defines divergent populations in two phase III randomized trials
Author(s) -
Michelle Petri,
Steven Watts,
Richard E. Higgs,
Matthew D. Linnik
Publication year - 2021
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/keab144
Subject(s) - medicine , concomitant , population , randomized controlled trial , systemic lupus erythematosus , immunology , disease , environmental health
Heterogeneity of SLE patients in clinical trials remains a challenge for developing new therapies. This study used a combinatorial analysis of four molecular biomarkers to define key sources of heterogeneity.