Open AccessMonocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis
Author(s) -
Shixian Chen,
Chunqing Guo,
Ran Wang,
Zhaoyong Feng,
Zheng Liu,
Lisheng Wu,
Di Zhao,
Songyuan Zheng,
Feilong Chen,
Dingding Zhang,
Jiajun Xu,
Ji-Xiao Zhu,
Xiaoguang Chen,
Zhanguo Li,
Christopher M. Wise,
Juan Li,
Xiangyang Wang
Publication year - 2020
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/keaa625
Subject(s) - osteoclast , osteolysis , medicine , immunology , proinflammatory cytokine , rankl , rheumatoid arthritis , bone resorption , myeloid derived suppressor cell , cancer research , suppressor , receptor , inflammation , activator (genetics) , endocrinology , cancer , surgery
While myeloid-derived suppressor cells (MDSCs) were previously shown to promote a proinflammatory T helper (Th) 17 response in autoimmune conditions, a potential impact of the MDSC-Th17 immune axis on abnormal bone destruction in RA remains largely unknown.