A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model | Zendy

Yufei Shi | Zendy; Hongjian Zhang | Zendy; Xin Zhang | Zendy; Zhan Chen | Zendy; Dan Zhao | Zendy; Jun Ma | Zendy

Open Access

A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model

Author(s) -

Yufei Shi,

Hongjian Zhang,

Xin Zhang,

Zhan Chen,

Dan Zhao,

Jun Ma

Publication year - 2019

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbz036

Subject(s) - sponge , pig skin , fish <actinopterygii> , chemistry , biomedical engineering , porosity , fishery , biology , food science , medicine , organic chemistry , botany

Collagen is widely used in biomedical applications due to its outstanding properties. In this study, highly porous sponge scaffolds were developed by using porcine skin-derived collagen (PSC) and fish scale-derived collagen (FSC), respectively. The morphology and composition of these PSC and FSC scaffolds were compared. The water uptake ratio of FSC scaffolds reached 47.8, which is 1.7 times of PSC scaffolds. The water vapour transmission rates (WVTR) of PSC and FSC scaffolds were 952.6 ± 55.5 and 1090.9 ± 77.1 g/m 2 /day, which could produce a moist healing environment for wounds. Both scaffolds show non-toxicity to L929 fibroblast cells. The burn wound healing efficiency of these two scaffolds was examined in vivo using rabbits. No scars around the wounds were observed after applying PSC and SFC scaffolds. Histopathological studies reveal that the wound treated with PSC and FSC scaffolds showed much better wound recovery than gauze and vaseline gauze groups. It was suggested that FSC scaffolds have great potential as same as PSC to be used as burn wound dressing materials.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research