Open AccessEffects of the physicochemical properties of gold nanostructures on cellular internalization
Author(s) -
Ningqiang Gong,
Shizhu Chen,
Shubin Jin,
Jinchao Zhang,
Paul Wang,
XingJie Liang
Publication year - 2015
Publication title -
regenerative biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.166
H-Index - 25
ISSN - 2056-3426
DOI - 10.1093/rb/rbv024
Subject(s) - internalization , nanomaterials , nanotechnology , nanostructure , colloidal gold , nanoparticle , chemistry , materials science , cell , biochemistry
Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedical applications. However, we still know a little about the basic problem of what really matters in fabrication of Au nanomaterials which can get into biological systems, especially cells, with high efficiency. An understanding of how the physicochemical properties of Au nanomaterials affect their cell internalization is of significant interest. Studies devoted to clarify the functions of various properties of Au nanostructures such as size, shape and kinds of surface characteristics in cell internalization are under way. These fundamental investigations will give us a foundation for constructing Au nanomaterial-based biomedical devices in the future. In this review, we present the current advances and rationales in study of the relationship between the physicochemical properties of Au nanomaterials and cell uptake. We also provide a perspective on the Au nanomaterial-cell interaction research.