Open AccessEfficacy of concentrated growth factors combined with mineralized collagen on quality of life and bone reconstruction of guided bone regeneration
Author(s) -
Yan Dai,
Xiaohui Han,
Lihua Hu,
Haiwei Wu,
Shengyun Huang,
Yupeng Lu
Publication year - 2020
Publication title -
regenerative biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.166
H-Index - 25
ISSN - 2056-3426
DOI - 10.1093/rb/rbaa007
Subject(s) - medicine , clinical trial , regeneration (biology) , surgery , quality of life (healthcare) , dentistry , implant , clinical efficacy , randomized controlled trial , swelling , nursing , biology , microbiology and biotechnology , pathology
To evaluate the clinical efficacy of concentrated growth factors (CGFs) combined with mineralized collagen (MC) in guided bone regeneration (GBR). A retrospective study involving 29 patients treated with GBR technique, which was performed either CGF and MC complexes or MC alone. Implants were inserted simultaneously and cone-beam computed tomography was taken immediately, at 3 and 6 months postoperation. Questionnaires were completed by all patients so as to evaluate the main symptoms and daily activities during the first week after surgery. The outcomes of the two groups were statistically compared. All implants healed uneventfully. Patients in both groups suffered from different levels of discomfort for the reason of swelling, pain and chewing impairment on 1-2 days. Meanwhile, swelling of the Trial group was weaker than the Control group. When compared with the Control group, pain levels in Trial group were more rapidly reduced and patients took fewer analgesics from Day 3. Furthermore, the reconstitution mean value of the graft was thicker at 3 and 6 months in Trial group. CGFs complex with MC were beneficial to relieve the clinical symptoms, promote the peri-implant bone regeneration and shorten the healing time.